49ers vs Colts Player Prop Predictions – NFL Week 16

Monday Night Football closes the week with a compelling NFC vs AFC matchup as Brock Purdy and the San Francisco 49ers travel to Indianapolis to face the Colts. With elite offensive talent on both sides and clear contrasts in play style, this matchup offers several strong angles for 49ers vs Colts player props on QuickPicks.

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Passing Yards Props for 49ers vs Colts

Brock Purdy — 244.5 Passing Yards — More

Purdy continues to thrive in Kyle Shanahan’s system, especially against defenses that struggle with motion and play-action. With multiple high-end weapons at his disposal, this number is well within reach. More is the lean for this 49ers vs Colts player prop.

Philip Rivers — 155.5 Passing Yards — Less

This is a low passing number, but San Francisco’s pass rush and coverage discipline make it difficult for opposing quarterbacks to sustain drives through the air. Expect Indianapolis to lean run-heavy, making Less the stronger side.

Receiving Yards Props for 49ers vs Colts

George Kittle — 60.5 Receiving Yards — More

Kittle thrives in matchup-based game plans, and Indianapolis has shown vulnerability to tight ends over the middle. His involvement in both play-action and red-zone looks makes More appealing among 49ers vs Colts player props.

Michael Pittman Jr. — 35.5 Receiving Yards — Less

Pittman’s line reflects uncertainty in Indy’s passing volume. Against a physical San Francisco secondary, targets may be limited and efficiency hard to come by. Less is the safer side here.

Rushing Yards Props for 49ers vs Colts

Jonathan Taylor — 97.5 Rushing Yards — More

If Indianapolis keeps this game competitive, it will be through Taylor. His workload and explosive rushing ability give him a strong chance to clear this number. More is a top-tier 49ers vs Colts player prop.

Christian McCaffrey — 63.5 Rushing Yards — More

McCaffrey remains the engine of San Francisco’s offense. Even in balanced game scripts, his rushing efficiency and red-zone usage push this line toward More.

Why QuickPicks for 49ers vs Colts Player Props

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49ers vs Colts Best Player Props Conclusion

This Monday Night Football matchup features clear offensive focal points on both sides. Expect efficient passing from Brock Purdy, heavy rushing volume from Jonathan Taylor, and consistent production from Christian McCaffrey and George Kittle. Together, these plays form the best 49ers vs Colts player props for Monday’s showdown — ideal anchors for your QuickPicks entry this week.