NFL Week 10 Pick’em 2025: Contests, Picks, and More

Week 10 of the 2025 NFL season arrives with playoff pushes intensifying and marquee matchups across every conference. While fans are searching for NFL week 10 pick’em sheets, Splash Sports is redefining how to play — through skill-based contests with automated scoring, mobile access, and guaranteed prizes.

Below, check out our NFL Week 10 Pick’em predictions and ATS picks to guide your contest strategy this week.

Top Week 10 NFL Pick’em Contests to Enter

Splash $100K High Stakes Pick All ATS – A $1,000 entry contest with $100,800 in guaranteed contest prizes. Players pick every game against the spread from Sunday through Monday Night Football, earning one point per correct selection and double points for a “Best Pick.” The top 10 finishers take home major payouts including $30,240 for first, $20,160 for second, and $15,120 for third. Multiple entries (3 max) are allowed.

Splash $5K High Stakes Pick All ATS – A $5,000 entry contest featuring $45,000 in guaranteed prizes. Entrants make ATS selections for all 13 games on the Week 6 slate and can lock in one “Best Pick” for double points. The top three finishers earn $21,000, $14,000, and $10,000 respectively. Single-entry only, for players ready for high-stakes competition.

Splash $15K NFL Pick All ATS – A $10 entry contest with $15,003 in guaranteed contest prizes. Players pick every NFL game against the spread and select a “Best Pick” worth double points. The top 100 finishers are paid out, highlighted by $1,905.83 for first, $1,500.30 for second, and $1,125.22 for third. Up to 50 entries per player are allowed, making this the most popular way to join the action.

NFL Pick’em Week 10 Predictions & Strategy

Raiders vs. Broncos (Thursday Night Football)

• Safe Pick (Winner): Broncos – Denver’s defense leads the way at home.
  
  
• Against the Spread (ATS): Broncos -9.5
  

Falcons vs. Colts (London, 9:30 AM ET)

• Safe Pick (Winner): Colts – Indy’s balanced offense prevails overseas.
  
  
• Against the Spread (ATS): Colts -6.5
  

Saints vs. Panthers

• Safe Pick (Winner): Saints – New Orleans surprises with strong QB play.
  
  
• Against the Spread (ATS): Saints +3.5
  

Giants vs. Bears

• Safe Pick (Winner): Bears – Chicago rides its running game to victory.
  
  
• Against the Spread (ATS): Bears -3
  

Jaguars vs. Texans

• Safe Pick (Winner): Texans – Houston’s young stars shine at home.
  
  
• Against the Spread (ATS): Texans -2.5
  

Bills vs. Dolphins

• Safe Pick (Winner): Dolphins – Miami’s offense stays hot in South Florida.
  
  
• Against the Spread (ATS): Dolphins +8.5
  

Ravens vs. Vikings

• Safe Pick (Winner): Ravens – Baltimore’s pass rush overwhelms Minnesota.
  
  
• Against the Spread (ATS): Ravens -3.5
  

Browns vs. Jets

• Safe Pick (Winner): Browns – Cleveland edges the Jets in a defensive slugfest.
  
  
• Against the Spread (ATS): Browns +1.5
  

Patriots vs. Buccaneers

• Safe Pick (Winner): Buccaneers – Tampa Bay protects home field behind a strong offensive effort.
  
  
• Against the Spread (ATS): Buccaneers -1.5
  

Cardinals vs. Seahawks

• Safe Pick (Winner): Seahawks – Seattle dominates at Lumen Field.
  
  
• Against the Spread (ATS): Seahawks -6
  

Rams vs. 49ers

• Safe Pick (Winner): 49ers – San Francisco controls both lines of scrimmage.
  
  
• Against the Spread (ATS): 49ers -3
  

Lions vs. Commanders

• Safe Pick (Winner): Lions – Detroit’s balanced attack secures another win.
  
  
• Against the Spread (ATS): Lions -3.5
  

Steelers vs. Chargers (Sunday Night Football)

• Safe Pick (Winner): Steelers – Rodgers delivers in primetime on the road.
  
  
• Against the Spread (ATS): Steelers  +4.5
  

Eagles vs. Packers (Monday Night Football)

• Safe Pick (Winner): Eagles – Jalen Hurts stays hot and helps the Eagles cover on Monday Night Football.
  
  
• Against the Spread (ATS): Eagles +3

Skill-Based Gameplay Tips

• Watch travel fatigue. The early London game can shake up normal performance trends — fade offensive overconfidence.
  
  
• Defensive matchups matter. Broncos, Ravens, and Jets are safe “Best Pick” options in low-total contests.
  
  
• Primetime picks swing contests. Stack higher confidence points on teams like the Chargers or Packers in your Splash Pick’em sheet.

Why Pick’em Contests Beat Pick’em Sheets

Fans still search for “NFL week 10 pick’em sheets,” but Splash Sports is the smarter, skill-based way to play:

• Automated scoring means instant updates.
  
  
• Mobile-friendly gameplay keeps you in control.
  
  
• Guaranteed contest prizes ensure winners always get paid.
  
  
• Skill-based competition rewards strategy, not luck.

It’s like your old pick’em sheet—but smarter, faster, and built for the modern fan.

Conclusion for NFL Week 10 Pick’em 2025

Week 10 brings critical matchups across the NFL landscape, from early-morning football in London to primetime showdowns in Los Angeles and Green Bay. Whether you’re playing Pick All, Confidence, or ATS contests, Splash Sports is the ultimate platform to test your NFL knowledge and skill. 

If you’re interested in our other contests, check out our NFL Week 10 Survivor picks and strategies.

👉 Ready to play? Check out the live NFL pick’em contests on Splash Sports and start building your winning sheet today.