NFL Week 12 Pick’em 2025: Contests, Picks, and More

Week 12 of the 2025 NFL season delivers a packed schedule of playoff-positioning battles and division rivalries. While many fans still search for NFL week 12 pick’em sheets, Splash Sports offers a modern, skill-based way to play—with automated scoring, guaranteed contest prizes, and a community built for friends competing together.

Below, you’ll find our NFL Week 12 Pick’em predictions and ATS picks—a balance of safe favorites and sharp underdogs to help you climb the leaderboard.

Top Week 12 NFL Pick’em Contests to Enter

Splash $50K High Stakes Pick All ATS – A $1,000 entry contest with $50,400 in guaranteed contest prizes. Players pick every game against the spread from Sunday through Monday Night Football, earning one point per correct selection and double points for a “Best Pick.” The top 10 finishers take home major payouts including $27,720 for first, $10,080 for second, and $6,300 for third. Multiple entries (3 max) are allowed.

Splash $5K High Stakes Pick All ATS – A $5,000 entry contest featuring $45,000 in guaranteed prizes. Entrants make ATS selections for all 13 games on the slate and can lock in one “Best Pick” for double points. The top three finishers earn $21,000, $14,000, and $10,000 respectively. Single-entry only, for players ready for high-stakes competition.

Splash $15K NFL Pick All ATS – A $10 entry contest with $15,003 in guaranteed contest prizes. Players pick every NFL game against the spread and select a “Best Pick” worth double points. The top 100 finishers are paid out, highlighted by $1,905.83 for first, $1,500.30 for second, and $1,125.22 for third. Up to 50 entries per player are allowed, making this the most popular way to join the action.

NFL Pick’em Week 12 Predictions & Strategy

Bills vs. Texans (Thursday Night Football)

• Safe Pick (Winner): Bills – Buffalo’s home-field advantage proves too much for Houston.
  
  
• Against the Spread (ATS): Texans +2.5 – C.J. Stroud and the Texans can keep this within a field goal.
  

Jets vs. Ravens

• Safe Pick (Winner): Ravens – Lamar Jackson shines at home against New York’s struggling offense.
  
  
• Against the Spread (ATS): Ravens -14.5 – Baltimore’s defense forces turnovers and wins convincingly.
  

Steelers vs. Bears

• Safe Pick (Winner): Bears – Chicago’s pass rush causes chaos for Pittsburgh’s offense.
  
  
• Against the Spread (ATS): Bears -1.5 – Caleb Williams’ mobility gives the Bears a narrow edge.
  

Patriots vs. Bengals

• Safe Pick (Winner): Bengals – Home crowd makes the difference in this one.
  
  
• Against the Spread (ATS): Bengals +5.5 – Cincinnati pulls away late to cover comfortably and even potentially win.
  

Giants vs. Lions

• Safe Pick (Winner): Lions – Detroit’s offensive line controls the game at home.
  
  
• Against the Spread (ATS): Lions -9.5 – The Giants’ offense won’t keep pace on the road.
  

Vikings vs. Packers

• Safe Pick (Winner): Packers – Green Bay rides home momentum in a close NFC North matchup.
  
  
• Against the Spread (ATS): Vikings +6.5 – Minnesota keeps it close with explosive plays downfield.
  

Colts vs. Chiefs

• Safe Pick (Winner): Chiefs – Kansas City’s experience wins out in the fourth quarter.
  
  
• Against the Spread (ATS): Colts +4.5 – Indy’s offense and defense is good enough to hang around.
  

Seahawks vs. Titans

• Safe Pick (Winner): Seahawks – Seattle controls the pace and edges Tennessee at home.
  
  
• Against the Spread (ATS): Seahawks -12.5 – If Darnold gets rolling, this could get ugly fast.
  

Jaguars vs. Cardinals

• Safe Pick (Winner): Jaguars – Trevor Lawrence is too much for the Cardinals defense in a back-and-forth battle.
  
  
• Against the Spread (ATS): Jaguars +1.5 – Jacksonville does just enough to cover.
  

Browns vs. Raiders

• Safe Pick (Winner): Raiders – Pete Carroll and his defense give Dillon Gabriel a hard time.
  
  
• Against the Spread (ATS): Raiders -1.5 – Expect a low-scoring grind, but Las Vegas outlasts the Browns.
  

Eagles vs. Cowboys (Game of the Week – 4:25 PM ET)

• Safe Pick (Winner): Cowboys – Dallas makes a statement at home with a balanced performance.
  
  
• Against the Spread (ATS): Cowboys +3.5 – The Cowboys’ defense holds off Hurts and Philly late.
  

Falcons vs. Saints

• Safe Pick (Winner): Saints – New Orleans leans on home-field advantage and a stingy defense.
  
  
• Against the Spread (ATS): Saints +3 – The Superdome remains one of the toughest places to play.
  

Buccaneers vs. Rams

• Safe Pick (Winner): Rams – Stafford’s connection with Nacua proves decisive.
  
  
• Against the Spread (ATS): Buccaneers +6.5 – Tampa puts up a fight as these 2 teams are playing for a top seed.
  

Panthers vs. 49ers (Monday Night Football)

• Safe Pick (Winner): 49ers – San Francisco’s roster depth overwhelms Carolina.
  
  
• Against the Spread (ATS): 49ers -6.5 – The Niners are elite in prime time, especially at home.

Skill-Based Gameplay Tips

• Don’t overvalue big spreads. Teams like Baltimore or Tennessee may win outright, but divisional underdogs often sneak inside the number.
  
  
• Prime-time contests are separators. Sunday and Monday games carry high scoring variance—use them strategically for “Best Pick” bonuses in Splash contests.
  
  
• Lean on balanced teams. In late-season matchups, well-rounded squads like Detroit, Dallas, and San Francisco tend to outperform boom-or-bust offenses.

Why Pick’em Contests Beat Pick’em Sheets

Fans still search for “NFL week 12 pick’em sheets,” but Splash Sports is the smarter, skill-based way to play:

• Automated scoring means instant updates.
  
  
• Mobile-friendly gameplay keeps you in control.
  
  
• Guaranteed contest prizes ensure winners always get paid.
  
  
• Skill-based competition rewards strategy, not luck.

It’s like your old pick’em sheet—but smarter, faster, and built for the modern fan.

Conclusion for NFL Week 12 Pick’em 2025

Week 12 offers everything from AFC shootouts to NFC playoff previews, capped by the Eagles vs. Cowboys rivalry under the national spotlight. Whether you’re building your lineup for Pick All, Confidence, or ATS contests, Splash Sports is where true NFL fans test their knowledge and skill every week.

If you’re interested in our other contests, check out our NFL Week 12 Survivor picks and strategies.

👉 Ready to play? Check out the live NFL pick’em contests on Splash Sports and start building your winning sheet today.