NFL Week 16 Pick’em 2025: Contests, Picks, and More

The playoff picture is heating up as the NFL rolls into Week 15 of the 2025 season. Contenders are separating from pretenders, and every pick carries playoff implications. While fans are still searching for “NFL week 15 pick’em sheets,” Splash Sports gives players the smarter, skill-based way to play—with automated scoring, mobile access, and guaranteed prizes in every contest.

Below, we’ve got your complete NFL Week 15 Pick’em predictions and ATS picks—a balanced mix of safe favorites and value-driven underdogs to help you climb the leaderboard.

Top Week 16 NFL Pick’em Contests to Enter

Splash $50K NFL Pick All ATS – A $1,000 entry contest with $50,400 in guaranteed contest prizes. Players pick every game against the spread from Sunday through Monday Night Football, earning one point per correct selection and double points for a “Best Pick.” The top 10 finishers take home major payouts including $27,720 for first, $10,080 for second, and $6,300 for third. Multiple entries (3 max) are allowed.

Splash $10K High Stakes Pick All ATS – A $10 entry contest featuring $10,008 in guaranteed prizes. Entrants make ATS selections for all 13 games on the slate and can lock in one “Best Pick” for double points. The top three finishers earn $1,271.17, $1,000.80, and $750.60 respectively. Single-entry only, for players ready for high-stakes competition.

Splash $100K CFB Bowl Pick'em – A $100 entry contest featuring $100,080 in guaranteed prizes. Entrants make ATS selections for all 16 games on the slate and can lock in one “Best Pick” for double points. The top three finishers earn $12,710.16, $10,008.00, and $7,506.00 respectively. Single-entry only, for players ready for high-stakes competition.

NFL Pick’em Week 16 Predictions & Strategy

Rams vs. Seahawks (Thursday Night Football)

• Safe Pick (Winner): Rams – Los Angeles is just too dominant at the moment, not even Seattle’s defense can stop their offense.
• Against the Spread (ATS): Rams +1.5 – McVay’s game planning keeps this tight; field-goal game either way.

Eagles vs. Commanders (Saturday 5:00 PM)

• Safe Pick (Winner): Eagles – Philly’s depth and pass rush overwhelm Washington.
• Against the Spread (ATS): Eagles -5.5 – The Commanders can’t protect long enough to keep up.

Packers vs. Bears (Saturday Night Football)

• Safe Pick (Winner): Bears – Soldier Field crowd and a surging defense lift Chicago late.
• Against the Spread (ATS): Bears +3 – NFC North rivalries rarely end in blowouts; value with the home dog.

Bills vs. Browns

• Safe Pick (Winner): Bills – Buffalo’s defense holds firm in cold December football.
• Against the Spread (ATS): Browns +8.5 – Cleveland’s defense keeps it closer than the market expects.

Rams vs. Cowboys

• Safe Pick (Winner): Cowboys – Dallas stays hot at home and leans on its defense.
• Against the Spread (ATS): Cowboys -1.5 – Dak and CeeDee connect for enough big plays to cover.

Chiefs vs. Titans

• Safe Pick (Winner): Chiefs – Kansas City locks up playoff seeding in a road rout.
• Against the Spread (ATS): Chiefs -11.5 – Tennessee’s offense won’t keep up with Mahomes.

Bengals vs. Dolphins

• Safe Pick (Winner): Dolphins – Miami’s track team offense thrives in home humidity.
• Against the Spread (ATS): Dolphins +1.5 – Wrong team favored; Dolphins win outright.

Jets vs. Saints

• Safe Pick (Winner): Saints – New Orleans’ defense shuts down the Jets’ passing attack.
• Against the Spread (ATS): Saints -3.5 – The Superdome edge and short fields help cover comfortably.

Vikings vs. Giants

• Safe Pick (Winner): Vikings – Minnesota’s passing attack finds its rhythm again.
• Against the Spread (ATS): Vikings -1.5 – Giants’ offense doesn’t have the juice to keep pace.

Buccaneers vs. Panthers

• Safe Pick (Winner): Buccaneers – Tampa Bay’s defense carries them on the road.
• Against the Spread (ATS): Buccaneers -1.5 – Carolina’s offense continues to struggle against pressure.

Jaguars vs. Broncos

• Safe Pick (Winner): Broncos – Denver’s defense slows down Trevor Lawrence in the cold.
• Against the Spread (ATS): Broncos -2.5 – Denver covers at home where their defense is elite.

Falcons vs. Cardinals

• Safe Pick (Winner): Cardinals – Arizona’s offense finds rhythm against Atlanta’s secondary.
• Against the Spread (ATS): Cardinals -1.5 – Jacoby Brissett's arm and home field make the difference.

Steelers vs. Lions

• Safe Pick (Winner): Lions – Detroit wins a physical, high-stakes home game.
• Against the Spread (ATS): Lions -6.5 – The Ford Field crowd fuels a statement December victory.

Raiders vs. Texans

• Safe Pick (Winner): Texans – C.J. Stroud dominates a weak Vegas defense.
• Against the Spread (ATS): Texans -12.5 – Houston cruises; the Raiders won’t be able to trade scores.

Patriots vs. Ravens (Sunday Night Football)

• Safe Pick (Winner): Ravens – Baltimore shines under the lights.
• Against the Spread (ATS): Ravens -2.5 – Lamar Jackson’s mobility is too much for New England’s front.

49ers vs. Colts (Monday Night Football)

• Safe Pick (Winner): 49ers – San Francisco stays sharp on the road.
• Against the Spread (ATS): Colts +6 – Indy’s offense can shorten the game enough to cover at home.

Skill-Based Gameplay Tips

• Cold-weather games favor defense. Buffalo, Chicago, and Denver matchups could swing low-scoring and tight.
• Don’t chase blowouts. Late-season double-digit favorites (like Kansas City and Houston) often rest starters in the second half—be careful in ATS formats.
• Prime-time edges. Teams like Seattle, Baltimore, and San Francisco historically thrive in night games—these are perfect “Best Pick” opportunities for Splash contests.

Why Pick’em Contests Beat Pick’em Sheets

Fans still search for “NFL week 16 pick’em sheets,” but Splash Sports is the smarter, skill-based way to play:

• Automated scoring means instant updates.
• Mobile-friendly gameplay keeps you in control.
• Guaranteed contest prizes ensure winners always get paid.
• Skill-based competition rewards strategy, not luck.

It’s like your old pick’em sheet—but smarter, faster, and built for the modern fan.

Conclusion for NFL Week 16 Pick’em 2025

Week 16 is packed with playoff implications and prime-time drama, from the NFC East clash in Washington to Lamar Jackson’s Sunday night showcase in Baltimore. Whether you’re playing Pick All, Confidence, or ATS contests, Splash Sports is the best platform to test your NFL knowledge and skill every week.

If you’re interested in our other contests, check out our NFL Week 16 Survivor picks and strategies.

👉 Ready to play? Check out the live NFL pick’em contests on Splash Sports and start building your winning sheet today.