NFL Week 6 Pick’em 2025: Contests, Picks, and More

Week 6 of the 2025 NFL season brings us a loaded slate with divisional rivalries, primetime blockbusters, and even an international matchup. Many fans still search for “NFL week 6 pick’em sheets,” but Splash Sports provides the modern way to play. With Pick’em contests, you get automated scoring, guaranteed contest prizes, and mobile access—no outdated paper tracking.

Below are our NFL Week 6 Pick’em predictions and ATS picks for every matchup.

Top Week 6 NFL Pick’em Contests to Enter

Splash $100K High Stakes NFL Pick All ATS – A $1,000 entry contest with $100,800 in guaranteed contest prizes. Players pick every game against the spread, with the top finishers competing for one of the biggest payouts of the season.

$100 NFL Pick All ATS – A $100 entry, head-to-head style contest with $180 in guaranteed prizes. Two players go head-to-head picking every game against the spread, winner takes all bragging rights and the payout.

$20 NFL Pick All Confidence – A $20 entry contest with $180 in guaranteed prizes. Ten players compete by assigning confidence points to every NFL game, with the top scorer taking home the prize.

NFL Week 6 Pick’em Predictions & Strategy

Eagles vs. Giants (Thursday Night Football)

• Safe Pick (Winner): Eagles – Philadelphia’s depth carries the night.
  
  
• Against the Spread (ATS): Eagles -7
  
  

Broncos vs. Jets (London – 9:30 AM ET)

• Safe Pick (Winner): Jets – Defense and special teams tilt this matchup overseas.
  
  
• Against the Spread (ATS): Jets +7.5
  
  

Rams vs. Ravens

• Safe Pick (Winner): Ravens – Baltimore too strong at home.
  
  
• Against the Spread (ATS): Ravens -5.5
  
  

Cowboys vs. Panthers

• Safe Pick (Winner): Cowboys – Dallas dominates in the trenches.
  
  
• Against the Spread (ATS): Cowboys -6.5
  
  

Cardinals vs. Colts

• Safe Pick (Winner): Colts – Indianapolis gets it done at home.
  
  
• Against the Spread (ATS): Colts -4.5
  
  

Seahawks vs. Jaguars

• Safe Pick (Winner): Jaguars – Jacksonville protects home field.
  
  
• Against the Spread (ATS): Jaguars -5.5
  
  

Chargers vs. Dolphins

• Safe Pick (Winner): Dolphins – Miami’s speed advantage is the difference.
  
  
• Against the Spread (ATS): Dolphins -3.5
  
  

Browns vs. Steelers

• Safe Pick (Winner): Steelers – Defense makes Heinz Field a tough place to play.
  
  
• Against the Spread (ATS): Steelers -3.5
  
  

Patriots vs. Saints

• Safe Pick (Winner): Saints – New Orleans leans on its defense.
  
  
• Against the Spread (ATS): Saints -3.5
  
  

Titans vs. Raiders

• Safe Pick (Winner): Raiders – Las Vegas edges Tennessee in a close one.
  
  
• Against the Spread (ATS): Raiders -3.5
  
  

49ers vs. Buccaneers

• Safe Pick (Winner): Buccaneers – Tampa Bay pulls off the home win.
  
  
• Against the Spread (ATS): Buccaneers +1.5
  
  

Bengals vs. Packers

• Safe Pick (Winner): Packers – Green Bay holds strong at Lambeau.
  
  
• Against the Spread (ATS): Packers -1.5
  
  

Lions vs. Chiefs (Sunday Night Football)

• Safe Pick (Winner): Chiefs – Mahomes shines under the lights.
  
  
• Against the Spread (ATS): Chiefs -5.5
  
  

Bills vs. Falcons (Monday Night Football – Game 1)

• Safe Pick (Winner): Bills – Buffalo too powerful on both sides.
  
  
• Against the Spread (ATS): Bills -13.5
  
  

Bears vs. Commanders (Monday Night Football – Game 2)

• Safe Pick (Winner): Commanders – Washington takes advantage at home.
  
  
• Against the Spread (ATS): Commanders -1.5

Skill-Based Gameplay Tips for NFL Week 6 Pick’em

• Focus on primetime games. Chiefs vs. Lions and Monday night’s doubleheader could swing contests.
  
  
• Beware big spreads. Buffalo looks safe, but -13.5 is tricky in ATS formats.
  
  
• International games are unpredictable. Lean on defense and QB play when picking the London matchup.

Why Pick’em Contests Beat Pick’em Sheets

Fans may still look for “NFL week 6 pick’em sheets,” but Splash Sports makes things smarter:

• Automated scoring – no manual tallying.
  
  
• Mobile access – make picks anywhere.
  
  
• Guaranteed contest prizes – winners always paid.
  
  
• Play against friends, not the house.
  
  

It’s like your old pick’em sheet—but upgraded for today’s NFL fan.

Conclusion for NFL Week 6 Pick’em 2025

NFL Week 6 features rivalries, primetime blockbusters, and another international showdown. Whether you’re playing in Pick All, Confidence, or ATS contests, Splash Sports is the best place to test your NFL knowledge and skill.

If you’re interested in our other contests, check out our NFL Week 6 Survivor picks and strategies.

👉 Ready to play? Check out the live NFL pick’em contests on Splash Sports and start building your winning sheet today.