College Football Pick’em Week 5: Predictions & Contests 2025

Week 5 of the 2025 college football season is loaded with headline matchups, from Alabama vs. Georgia to Ohio State vs. Washington. Many fans are still searching for college football pick’em printable sheets week 5, but the smarter way to play is through skill-based contests on Splash Sports. Instead of outdated paper sheets, you’ll get automated scoring, mobile access, and real-money competition with your friends.

This week’s schedule includes playoff-shaping battles in the SEC, Big Ten, and Pac-12. Below, we’ll break down our CFB week 5 college pick’em predictions with both safe winners and ATS leans.

Top College Football Pick’em Week 5 Contests to Enter

Here are three of the best contests you can join for college football pick’em week 5:

Kelly's $10K CFB Pick’em ATS Week 5

• Creator: kellyinvegas
  
  
• $25 Entry | $10,012.50 in Contest Prizes
  
  
• Entry Deadline: Sat 12:00 PM

Splash $1K CFB Pick’em ATS Week 5

• Creator: Splash
  
  
• $10 Entry | $1,008 in Contest Prizes
  
  
• Entry Deadline: Sat 12:00 PM

CFB Week 5 Pick’em League

• Creator: mikezakarian
  
  
• $10 Entry | $4,375 in Contest Prizes
  
  
• Entry Deadline: Sat 12:00 PM

Play in one—or all—of these contests to test your skill against the community.

College Football Week 5 Pick’em Predictions & Strategy

Florida State Seminoles vs Virginia Cavaliers (9/26, 7:00 PM)

• Safe Pick (Winner): Florida State
  
  
• Against the Spread (ATS): Florida State -7
  
  

TCU Horned Frogs vs Arizona State Sun Devils (9/26, 9:00 PM)

• Safe Pick (Winner): TCU
  
  
• ATS: TCU -2.5
  
  

Georgia Tech Yellow Jackets vs Wake Forest Demon Deacons (9/27, 12:00 PM)

• Safe Pick (Winner): Wake Forest
  
  
• ATS: Wake Forest +14
  
  

USC Trojans vs Illinois Fighting Illini (9/27, 12:00 PM)

• Safe Pick (Winner): USC
  
  
• ATS: USC -6.5
  
  

Notre Dame Fighting Irish vs Arkansas Razorbacks (9/27, 12:00 PM)

• Safe Pick (Winner): Notre Dame
  
  
• ATS: Notre Dame -5.5
  
  

Utah State Aggies vs Vanderbilt Commodores (9/27, 12:45 PM)

• Safe Pick (Winner): Vanderbilt
  
  
• ATS: Vanderbilt -22.5
  
  

Indiana Hoosiers vs Iowa Hawkeyes (9/27, 3:30 PM)

• Safe Pick (Winner): Iowa
  
  
• ATS: Iowa +7.5
  
  

LSU Tigers vs Ole Miss Rebels (9/27, 3:30 PM)

• Safe Pick (Winner): LSU
  
  
• ATS: Ole Miss +2.5
  
  

Auburn Tigers vs Texas A&M Aggies (9/27, 3:30 PM)

• Safe Pick (Winner): Texas A&M
  
  
• ATS: Texas A&M -6.5
  
  

Ohio State Buckeyes vs Washington Huskies (9/27, 3:30 PM)

• Safe Pick (Winner): Ohio State
  
  
• ATS: Ohio State -8.5
  
  

Tennessee Volunteers vs Mississippi State Bulldogs (9/27, 4:15 PM)

• Safe Pick (Winner): Tennessee
  
  
• ATS: Tennessee -7.5
  
  

Arizona Wildcats vs Iowa State Cyclones (9/27, 7:00 PM)

• Safe Pick (Winner): Iowa State
  
  
• ATS: Iowa State -5.5
  
  

Oregon Ducks vs Penn State Nittany Lions (9/27, 7:30 PM)

• Safe Pick (Winner): Oregon
  
  
• ATS: Oregon +3.5
  
  

UMass Minutemen vs Missouri Tigers (9/27, 7:30 PM)

• Safe Pick (Winner): Missouri
  
  
• ATS: Missouri -44.5
  
  

Alabama Crimson Tide vs Georgia Bulldogs (9/27, 7:30 PM)

• Safe Pick (Winner): Georgia
  
  
• ATS: Alabama +3
  
  

BYU Cougars vs Colorado Buffaloes (9/27, 10:15 PM)

• Safe Pick (Winner): Colorado
  
  
• ATS: Colorado -6.5
  
  

Skill-Based Gameplay Tips for Week 5 College Football Pick’em

When playing in college football pick’em contests, remember these strategies:

• Focus on conference trends—Big Ten defenses and SEC road games often swing results.
  
  
• Mix Safe Picks with ATS awareness to maximize points.
  
  
• Don’t chase upsets—consistency wins long-term in contests.
  
  

Why Pick’em Contests Beat Pick’em Sheets

Many players still search for NCAAF pick’em week 5 sheets or “printable sheets.” But Splash Sports offers the modern alternative:

• Automated Scoring: No manual tallies needed.
  
  
• Mobile Access: Make picks anytime, anywhere.
  
  
• Skill-Based Gameplay: Outcomes are determined by knowledge and strategy, not luck.
  
  
• Community Competition: Play with friends, leagues, and commissioners in real-money contests.

It’s like your old pick’em sheet, but smarter and built for today’s college football fan.

Conclusions on Week 5 CFB Pick’em

Week 5 brings high-stakes matchups across the SEC, Big Ten, ACC, and Pac-12. Whether you’re backing Ohio State, Georgia, or a dark horse like Iowa State, the best way to test your college football knowledge and skill is by joining contests on Splash Sports.

👉 Explore more College Football pick'em contests, dive into college football action, and bring your friends along for the ride. Play against your friends, not the house.