NFL Week 5 Pick’em 2025: Contests, Picks, and More

The NFL season is heating up as we enter Week 5 of the 2025 season. Fans are hunting for “NFL week 5 pick’em sheets” to make their picks, but those paper sheets are outdated. Splash Sports offers a smarter way to play—automated scoring, mobile entries, and guaranteed contest prizes.

Here’s a complete breakdown of our NFL Week 5 Pick’em predictions and ATS picks for every game on the slate. 

Top Week 5 NFL Pick’em Contests to Enter

Splash $100K High Stakes NFL Pick All ATS – A $1,000 entry contest with $100,800 in guaranteed contest prizes. Players pick every game against the spread, with the top finishers competing for one of the biggest payouts of the season.

$100 NFL Pick All ATS – A $100 entry, head-to-head style contest with $180 in guaranteed prizes. Two players go head-to-head picking every game against the spread, winner takes all bragging rights and the payout.

$20 NFL Pick All Confidence – A $20 entry contest with $180 in guaranteed prizes. Ten players compete by assigning confidence points to every NFL game, with the top scorer taking home the prize.

NFL Week 5 Pick’em Predictions & Strategy

49ers vs. Rams (Thursday Night Football)

• Safe Pick (Winner): Rams – Los Angeles handles business at home.
  
  
• Against the Spread (ATS): Rams -3
  
  

Vikings vs. Browns (London)

• Safe Pick (Winner): Vikings – Minnesota’s balanced offense prevails overseas.
  
  
• Against the Spread (ATS): Vikings -4.5
  
  

Texans vs. Ravens

• Safe Pick (Winner): Ravens – Baltimore overwhelms Houston.
  
  
• Against the Spread (ATS): Ravens -9.5
  
  

Dolphins vs. Panthers

• Safe Pick (Winner): Dolphins – Miami’s speed is the difference.
  
  
• Against the Spread (ATS): Dolphins -1.5
  
  

Raiders vs. Colts

• Safe Pick (Winner): Colts – Indy’s defense makes the key stops.
  
  
• Against the Spread (ATS): Colts -6
  
  

Giants vs. Saints

• Safe Pick (Winner): Giants – New York squeaks by in a close one.
  
  
• Against the Spread (ATS): Giants -1.5
  
  

Cowboys vs. Jets

• Safe Pick (Winner): Cowboys – Dallas’ defense locks it down.
  
  
• Against the Spread (ATS): Cowboys -1.5
  
  

Broncos vs. Eagles

• Safe Pick (Winner): Eagles – Philly’s depth carries the day.
  
  
• Against the Spread (ATS): Eagles -4.5
  
  

Titans vs. Cardinals

• Safe Pick (Winner): Cardinals – Arizona protects home field.
  
  
• Against the Spread (ATS): Cardinals -7.5
  
  

Buccaneers vs. Seahawks

• Safe Pick (Winner): Seahawks – Seattle edges Tampa in a close one.
  
  
• Against the Spread (ATS): Seahawks -1.5
  
  

Lions vs. Bengals

• Safe Pick (Winner): Lions – Detroit is too strong at home.
  
  
• Against the Spread (ATS): Lions -7.5
  
  

Commanders vs. Chargers

• Safe Pick (Winner): Chargers – Herbert finds a way at home.
  
  
• Against the Spread (ATS): Chargers -2.5
  
  

Patriots vs. Bills (Sunday Night Football)

• Safe Pick (Winner): Bills – Buffalo cruises at home.
  
  
• Against the Spread (ATS): Bills -10
  
  

Chiefs vs. Jaguars (Monday Night Football)

• Safe Pick (Winner): Chiefs – Mahomes in primetime is tough to go against.
  
  
• Against the Spread (ATS): Chiefs -3

Skill-Based Gameplay Tips for NFL Week 5 Pick’em

• Target strong home teams. Baltimore, Detroit, and Kansas City are tough to fade at home.
  
  
• Don’t get trapped by huge spreads. While Buffalo looks safe straight-up, laying double digits is risky in ATS contests.
  
  
• London games are unpredictable. Lean on defenses and stable QB play when picking international matchups.

Why Pick’em Contests Beat Pick’em Sheets

While fans may still search for “NFL week 5 pick’em sheets,” Splash Sports delivers the modern solution:

• Automated scoring so you don’t have to track results.
  
  
• Mobile-friendly play lets you enter and update picks anywhere.
  
  
• Contest prizes guaranteed for winners.
  
  
• Play with friends, not against the house.
  
  

It’s like your old pick’em sheet—but smarter, skill-based, and built for today’s players.

Conclusion for NFL Week 5 Pick’em 2025

Week 5 features international action in London, divisional battles, and primetime showdowns with playoff implications. Whether you’re entering Pick All or Confidence contests, Splash Sports is the ultimate way to test both your NFL knowledge and skill.

If you’re interested in our other contests, check out our NFL Week 5 Survivor picks and strategies.

👉 Ready to play? Check out the live NFL pick’em contests on Splash Sports and start building your winning sheet today.