Panthers vs 49ers Player Prop Predictions – NFL Week 12

Week 12 wraps up with a Monday Night Football showdown as Brock Purdy and the San Francisco 49ers host Bryce Young and the Carolina Panthers. With a top-tier San Francisco offense facing a rebuilding Panthers unit, this slate offers strong value for Panthers vs 49ers player props on QuickPicks.

Looking for more ways to play this week? Don’t miss our Week 12 NFL Survivor picks and Week 12 NFL Pick’em breakdown for deeper strategy.

Passing Yards Props for Panthers vs 49ers

Brock Purdy — 250.5 Passing Yards — More

Purdy continues to operate one of the league’s most efficient offenses, and with a healthy lineup of weapons, he’s primed for another productive outing. Carolina’s defense has struggled to slow down well-schemed passing attacks, making More the ideal pick for this Panthers vs 49ers player prop.

Bryce Young — 202.5 Passing Yards — Less

Young faces a fierce 49ers front that creates constant pressure and forces quick decisions. Playing on the road in prime time against an elite defense sets up a challenging environment. Less is the sharper angle for this passing yards prop.

Receiving Yards Props for Panthers vs 49ers

Tetairoa McMillan — 61.5 Receiving Yards — Less

McMillan has flashed talent, but Carolina’s passing offense remains inconsistent. Against a disciplined San Francisco secondary and with limited big-play opportunities, Less feels like the right call for this Panthers vs 49ers player prop.

George Kittle — 56.5 Receiving Yards — More

Kittle thrives in matchups where linebackers and safeties struggle to keep up with play-action misdirection. Carolina has had difficulty containing athletic tight ends, giving Kittle a strong path to hitting More on this receiving line.

Rushing Yards Props for Panthers vs 49ers

Rico Dowdle — 76.5 Rushing Yards — Less

Dowdle has taken on an increased role, but San Francisco’s front seven is one of the stingiest in football. Game script may also force Carolina into more passing than running. Less is the smart play here.

Christian McCaffrey — 69.5 Rushing Yards — More

McCaffrey is always a top rushing-yard candidate, and this number sits in a very hittable range given his workload and efficiency. Against his former team, and with San Francisco likely playing with a lead, More is the preferred pick among Panthers vs 49ers player props.

Why QuickPicks for Panthers vs 49ers Player Props

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Panthers vs 49ers Best Player Props Conclusion

This Week 12 NFC matchup presents clear edges on both sides of the ball. Expect efficient production from Purdy, explosive involvement from McCaffrey, and limited output from the Panthers’ young offense. These selections make up the Panthers vs 49ers best player props for Monday’s contest — perfect additions to your QuickPicks entry this week.