NFL Week 1 Pick’em 2025: Contests, Picks, and More

The NFL returns in full force this fall, and the excitement couldn't be higher. Fans are already searching for “NFL week 1 pick'em sheets,” but why rely on a static sheet when you can play a skill-driven, real-money Pick’em Contest with automated scoring, mobile access, and instant results? 

At Splash Sports—Play Against Your Friends, Not the House—our NFL Pick’em Contests bring your group together in strategic competition that rewards knowledge, not luck.

Top NFL Pick’em Contests to Enter

Get in on the action with some of the most exciting NFL Week 1 Pick’em Contests already live on Splash:

• Splash NFL $250K Pick 5 – ATS Season Long – Choose 5 teams against the spread each week in this season-long contest. With  $250,000 in prizes and a $100 entry, it’s built for skilled players who want to prove their knowledge all season.
• Splash NFL $75K Pick All – Confidence Season Long – Rank your picks by confidence every week across the entire NFL season. A $100 entry gets you into a contest with $75,000 in prizes with big bragging rights on the line.
• Splash NFL $20K Week 1 Pick All ATS – Focus on just Week 1 with this ATS format contest. A $10 entry gives you a shot at a $20,000 prize —perfect for contest players looking for early-season edges.
• ‍Splash NFL $15K Week 1 Pick All Confidence – Test your strategy in a single-week confidence format. With $15,000 in prizes on the line for just a $50 entry, this is a great way to kick off the season with skill-driven picks.

NFL Pick’em Predictions & Strategy

Here’s the official Week 1 schedule from NFL.com with spreads from Yahoo, SportsLine, and CBS Sports. Use these Safe Picks and ATS leans to star st your contest lineups.

Philadelphia Eagles vs. Dallas Cowboys

• Safe Pick (Winner): Eagles
• ATS: Eagles –7
• Defending champs open at home with a banner night—stick with Philly to start their title defense strong.
  

Kansas City Chiefs vs. Los Angeles Chargers

• Safe Pick (Winner): Chiefs
• ATS: Chiefs –2.5
• The Chiefs remain the class of the AFC, even in Brazil—a Friday night statement game.
  

Tampa Bay Buccaneers vs. Atlanta Falcons

• Safe Pick (Winner): Buccaneers
• ATS: Bucs –1.5
  

Cincinnati Bengals vs. Cleveland Browns

• Safe Pick (Winner): Bengals
• ATS: Bengals –4.5
• Cincinnati’s recent dominance in this rivalry carries into Week 1.
  

Miami Dolphins vs. Indianapolis Colts

• Safe Pick (Winner): Dolphins
• ATS: Dolphins +1.5
• Miami’s speed on offense should overwhelm Indy’s young secondary.
  

Carolina Panthers vs. Jacksonville Jaguars

• Safe Pick (Winner): Jaguars
• ATS: Jaguars –3.5
  

Las Vegas Raiders vs. New England Patriots

• Safe Pick (Winner): Patriots
• ATS: Patriots –3.5
• New coach Mike Vrabel has them ready early.
  

Arizona Cardinals vs. New Orleans Saints

• Safe Pick (Winner): Saints
• ATS: Saints slight favorite
  

Pittsburgh Steelers vs. New York Jets

• Safe Pick (Winner): Jets
• ATS: Jets (pick’em range)
  

New York Giants vs. Washington Commanders

• Safe Pick (Winner): Commanders
• ATS: Commanders –7.5
  

Tennessee Titans vs. Denver Broncos

• Safe Pick (Winner): Broncos
• ATS: Broncos –7.5
• As the only Week 1 game with a spread over a touchdown, expect Denver’s defense to roar.
  

San Francisco 49ers vs. Seattle Seahawks

• Safe Pick (Winner): 49ers
• ATS: 49ers –1.5
  

Detroit Lions vs. Green Bay Packers

• Safe Pick (Winner): Packers
• ATS: Packers –1.5
  

Houston Texans vs. Los Angeles Rams

• Safe Pick (Winner): Rams
• ATS: Rams –2.5
  

Baltimore Ravens vs. Buffalo Bills

• Safe Pick (Winner): Bills
• ATS: Bills slight edge
• A can’t-miss Sunday night showdown featuring MVP quarterbacks.
  

Minnesota Vikings vs. Chicago Bears

• Safe Pick (Winner): Bears
• ATS: Bears –1
  

Tips for NFL Pick’em Week 1

1. Track trends, not hype – Underdogs of 6+ points cover nearly 70% of the time in Week 1 historically.
2. Manage confidence wisely – Save top confidence picks for clear mismatches like Broncos vs. Titans.
3. Leverage rivalries – Teams like Bengals vs. Browns often follow long-term trends.
4. Play the long game – Winning contests comes from consistent, skilled selections across the slate.
   

Why NFL Pick’em Contests Beat Pick’em Sheets

Many fans are still downloading “NFL week 1 pick’em sheets,” but Splash Sports gives you the modern alternative:

• Automated scoring & live leaderboards — no manual math.
• Play anywhere, anytime — mobile-friendly contests with instant results.
• Built for friends & groups — create or join contests with your community.
• Skill over luck — success comes from strategy and NFL knowledge.
• Contest prizes — transparent, guaranteed payouts, no “house take.”
  

It’s like your old pick'em sheet, but smarter, skill-based, and built for today’s players.

Conclusion

Week 1 sets the tone for the season—so make your NFL Pick’em Contest entries count. With marquee matchups like Eagles vs. Cowboys and Ravens vs. Bills, the stage is set for skillful picks to shine. Forget outdated paper pick'em sheets—join Splash Sports, rally your friends, and prove your NFL knowledge and skill for real contest prizes.

👉 Ready to play? Check out the live NFL pick’em contests on Splash Sports and start building your winning sheet today.